Research

Cancer Mechanobiology

Biophysical forces can guide tumour cell invasion, proliferation, and resistance, but the fundamental mechanisms governing such mechanosensitivity have yet to be uncovered. We develop computational and in-vitro models to provide new understanding and motivate novel mechanotherapeutics.

Growth and Remodelling of Cells and Tissue

Cells generate active forces both through remodelling of the actomyosin cytoskeleton and during swelling and tissue growth. Our group employs a range of computational methods including non-linear finite element analysis, agent-based models, and numerical analysis to explore the complex biomechanical behaviour of cells and tissue.

Immune-Mediated Disease

Efficient remyelination remains an unmet clinical need that has the potential to be functionally restorative for patients with MS. Immune cells are increasingly recognised as key players in modulating tissue regeneration, motivating us to investigate the mechanisms of force-sensitivity in immune cell remodelling by coupling advanced computational methods with ex-vivo analyses and theoretical biophysics.